법랑모세포섬유-치아종으로부터 발생한 법랑모세포섬유육종 -증례 보고-
A case of Ameloblastic Fibrosarcoma Transformed from Ameloblastic Fibro-odontoma
Shadavlonjid Bazarsad, 조은애, 남웅, 김현실, 육종인, 김진,
소속 상세정보
( Shadavlonjid Bazarsad ) - 연세대학교 치과대학 구강병리학교실
조은애 ( Cho Eun-Ae ) - 연세대학교 치과대학 구강병리학교실
남웅 ( Nam Woong ) - 연세대학교 치과대학 구강악안면외과학교실
김현실 ( Kim Hyun-Sil ) - 연세대학교 치과대학 구강병리학교실
육종인 ( Yook Jong-In ) - 연세대학교 치과대학 구강병리학교실
김진 ( Kim Jin ) - 연세대학교 치과대학 구강병리학교실
KMID : 0829220170410010045
Abstract
Ameloblastic fibrosarcoma (AFS) is an extremely rare malignant odontogenic tumor characterized with benign ameloblastic cells islands and malignant mesenchymal component. While two-thirds of AFS seem to arise de novo, but one-third develops from recurrent ameloblastic fibroma (AF) or ameloblastic fibro-odontomas (AFO). Pathological distinction of malignant transformation is essential for appropriate treatment. The patient was a 28 years old man. Since the primary tumor was excised, the mass recurred 2 years later. The recurrent tumor was diagnosed as AFS. Chief complaint was pain in the right mandible. Computer tomography finding revealed multilocular intrabony lesion with radiopaque substance in the primary lesion. In the recurrent lesion cortical bone destruction was found. Microscopically, both the primary and recurrent lesions showed benign ameloblastic follicles with myxoid or highly cellular mesenchymal proliferation. The histological difference between primary and recurrent lesions were that foci of dental hard tissue composed of enamel and dentin were found only in the primary lesion, whereas nuclear pleomorphism was aggrevated in the recurrent lesion. The histological criteria determining malignancy were discussed.
키워드
Ameloblastic fibro-odontoma; Ameloblastic fibrosarcoma; Malignant transformation
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